For clinicians & guideline committees

Recommendations that move when the evidence moves.

Living reviews flag the day a pooled estimate moves, so recommendations stay aligned with the evidence — and every effect estimate links back to the study it came from.

Read the validation case study
Living reviews · treatment networks · source-linked estimates
Forest plotlive
Random-effects pool · primary outcome6 studies
Smith 20240.62 [0.41, 0.94]
Chen 20230.71 [0.55, 0.92]
Patel 20240.83 [0.62, 1.11]
Garcia 20230.74 [0.58, 0.95]
Okafor 20240.88 [0.71, 1.09]
Müller 20221.05 [0.78, 1.41]
Pooled (RE)0.78 [0.65, 0.93]
study estimatepooled (RE)
RR, log scale
The shift

From guidelines that age to evidence that keeps pace.

Same workflow, two states. Flip the switch to see what changes.

Live · re-runs as trials are indexed

The evidence base
Re-runs as new trials are indexed
living
New RCTs
Flagged the day they’re indexed
days
The recommendation
Moves when the evidence moves
current
Tracking the pooled estimate as it changes
How it works

The evidence base, kept current for you.

Build the review once, let it re-run as new trials are indexed, and inspect every estimate back to its source.

Build

Build the comparison once

  • A systematic review and a network meta-analysis
  • Anchored against every relevant comparator
  • Defensible from the first submission
Keep live

Re-runs on a schedule

  • The whole pipeline re-runs on a cadence
  • Flags when a new trial moves the result
  • A signed record of what changed, each cycle
Inspect

No black box

  • Deterministic statistics — same inputs, same result
  • Every estimate traces to its source study
  • Change an assumption and re-run
Why trust it

Conclusions that hold up in peer review.

Validation

We reproduced a published meta-analysis: 3 of 4 endpoints within 6%.

One analyst rebuilt a peer-reviewed meta-analysis end to end in 2 days. Pooled estimates for three of four endpoints landed within 6% of the published values, and the case study explains the fourth. The statistics are deterministic: the same inputs always give the same result.

Read the case study

Comparisons a committee will accept

Pairwise and network meta-analysis, plus population-adjusted indirect comparisons, with certainty grading — every step inspectable.

  • Network meta-analysis
  • MAIC
  • STC
  • ML-NMR
  • Custom methods
  • GRADE certainty

Keep every recommendation aligned with the evidence behind it.

Read quickstart
Questions

The details.

A completed review re-runs on a schedule and flags the day a pooled estimate moves, so the committee learns a recommendation may need revisiting as soon as the evidence changes.